The mDOT Center

Transforming health and wellness via temporally-precise mHealth interventions

mHealth Center for Discovery, Optimization &
Translation of Temporally-Precise Interventions

Transforming health and welllness via temporally-precise mHealth interventions
The mHealth Center for Discovery, Optimization & Translation of Temporally-Precise Interventions (the mDOT Center) provides the methods, tools, and infrastructure for researchers to discover, optimize and deploy temporally-precise mHealth interventions to address growing public health problems.

Organized around three Technology Research & Development (TR&D) projects, the mDOT Center represents a unique national resource that is developing multiple methodological and technological innovations. Each TR&D is creating technological resources for the biological community that include easily deployable wearables, apps for wearables and smartphones, and a companion mHealth cloud system, all of which are open-source.

Health Needs

One of the biggest drivers of the nation’s rising healthcare spending is providing care for patients with chronic diseases, many of which are linked to health behaviors such as poor diet, lack of exercise, and smoking. A key strategy for making self-care and preventive measures more achievable has been the integration of passive monitoring into everyday life via mobile sensors and providing personalized information and guidance to patients.

mHealth Solutions

mDOT Center tools transform the ability of researchers to leverage the full range of available sensors and mobile technologies, allowing them to deliver dynamically personalized and temporally-precise mHealth interventions to individuals. These interventions can precipitate a much-needed transformation by enabling patients to initiate and sustain the lifestyle choices necessary to prevent or manage the burden of chronic health conditions.



The mDOT Center develops methods of identifying the ideal moments when health risks are elevated yet mitigatable. Our technologies have a significant potential to advance the fundamental understanding of health and behavior by supporting the analysis of complex, longitudinal, mHealth data.



To maximize the chances of success, mobile health intervention content is optimized to address the key drivers of current risk. The mDOT Center addresses these challenges by developing advanced reinforcement learning methods so that they can be applied to the case of mHealth interventions.



The mDOT Center resources make remote care possible for patients who have traditionally required close involvement of clinicians, marking a major transformation in care delivery. Our deliverables enable much greater personalization of mHealth interventions by expanding access to emerging biomarkers.

The mDOT Center currently teams with eight collaborative projects (CPs), each of which make a unique contribution from their respective sites across the country. These collaborations encompass several health targets including addictive behavior, sedentary behavior, cardiovascular diseases, oral health, and mental health. Our CPs cover analysis of data from observational studies, theory development, intervention design, development, testing, and novel sensor and biomarker development.


The mDOT Center has assembled a unique set of service projects (SPs). As the goal of the mDOT Center is to create new mHealth technological assets in the research community, successful transition to a diverse group of service projects, whose needs are being served by mDOT Center technologies, is essential to test and enhance the research utility of the mDOT Center. These SPs are well-equipped to test and deploy mDOT Center technologies as soon as they become available.


Become a Collaborative or Service Project.

Join us in developing the tools and technologies to transform healthcare.